The first time I visited Italy, it was just North Italy. We landed in Venice and drove to Trentino in our rental car. The second time was in South Italy where we spent one entire month in Puglia. We actually drove from Germany to Puglia but realized it would have been easier to just fly to Bari or Brindisi and drive a rental car from there. For the purpose of travel, it is important to understand what are the regions of Italy. You can pick and choose some of them or get a taste of them all. Here are the regions in Italy that you can visit – Northeast Italy, (the Dolomites, Trentino, Venice and Bologna) Northwest Italy, (Cinque Terre, Milan and the Alps) Central Italy, (Tuscany region and Rome) Southern Italy, (Naples, Puglia, Amalfi and Capri) The islands – Sicily and Sardinia. If you ever see the list of the most visited countries in the world, Italy usually is in top 5 year after year. It is because there is so much to see & experience in every single region of Keep in mind that to properly explore each region of Italy, you would probably need at least two weeks each. However, this itinerary focuses on the entire Italy, so I will help you move from one region to another and tell you the best of each. That’s the difference between a region-specific itinerary and a country-specific itinerary. Matera in Puglia, Italy road trip two weeks itinerary – via Pixabay If you think you will get to visit Italy multiple times, then by all means pick just one region or maximum two for each trip. If you’re going to visit Italy just once or twice in your life then I suggest you visit more than just 2 regions because they all have something to offer. on’t try to cover it all, it isn’t possible to do so. Instead, pick a few destinations and spend some quality time in each place that you visit so that you don’t feel rushed or drained out.